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Neither is an absolute criterion; both safety and efficacy are evaluated relative to how the treatment is intended to be used, what other treatments are available, and the severity of the disease or condition. For example, many drugs to treat cancer have severe side effects that would not be acceptable for an over-the-counter pain medication, yet the cancer drugs have been approved since they are used under a physician's care, and are used for a life-threatening condition.People over 55 (or a similar cutoff age) are often excluded from trials because their greater health issues and drug use complicate data interpretation, and because they have different physiological capacity than younger people.Clinical trials can vary in size and cost, and they can involve a single research center or multiple centers, in one country or in multiple countries.Clinical study design aims to ensure the scientific validity and reproducibility of the results.Whereas JPG 20 is the smallest file size, but may look more compressed. SVG, actually stands for Scalable Vector Graphics, and it' an image file that can be viewed at any size and still looks great.

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When participants are healthy volunteers who receive financial incentives, the goals are different than when the participants are sick.

During dosing periods, study subjects typically remain under supervision for one to 40 nights.

These authorities are responsible for vetting the risk/benefit ratio of the trial – their approval does not mean that the therapy is 'safe' or effective, only that the trial may be conducted.

Depending on product type and development stage, investigators initially enroll volunteers or patients into small pilot studies, and subsequently conduct progressively larger scale comparative studies.

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