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It calibrates movements in the face of a changing environment to coordinate them in a very precise way," lead author, Megan Carey, said in a statement.Carey is the principal investigator and group leader of the Neuroscience Program at the Champalimaud Center for the Unknown in Lisbon, Portugal.According to Albergaria, "The cerebellum is a well-conserved structure across species and there are circuits that are common across species." She speculates that future research based on these findings could help us better understand how locomotion influences associative learning in the human cerebellum."We tend to think that to manipulate the plasticity of the brain, so that people learn faster and slow learners improve, we have to use drugs.The main takeaway from this study is that the faster mice ran on a treadmill, the faster and better their cerebellum learned an associative task called "delay eyeblink conditioning." The authors describe the method of their latest research: “Here we investigated the effects of behavioral state, and specifically locomotor activity, on delay eyeblink conditioning, a cerebellum-dependent form of associative learning.In delay eyeblink conditioning, animals learn to close their eye in response to an initially neutral conditioned stimulus (CS) that is reliably predictive of an aversive unconditioned stimulus (US), such as a puff of air to the eye.” To gain a better understanding of the cellular changes that accompany learning in the cerebellum, Carey and colleagues developed a conditioned learning task of teaching mice to blink their eyes in response to a flash of light that was coupled with a puff of air, while running at various speeds on a treadmill.Bott, Eliza Kienitz, Yin-hsuan Chien, Daniel WC Hong, Ning Liu, Adam Royalty, Grace Hawthorne, and Allan L. Explore the neighborhood near our hotel in Columbus/Polaris first.
Faster treadmill running speeds enhance associative learning in the cerebellum of mice, according to a new study by researchers at the Champalimaud Center for the Unknown. Meet and pose questions to an array of art personalities, from appropriation to Andy Warhol, but be quick—time with the bachelors and bachelorettes is limited! Join Gen Wex, the center’s young patron initiative, on Valentine’s Day to get to know contemporary art movements, concepts, and artists.But here, all we had to do was control how fast mice were running to obtain an improvement.It would be interesting to see if this holds for humans, for cerebellar forms of learning — and even for other types of learning," Carey said in a statement.